Chronic disease Epidemiology and Multimorbidity Epidemiology, with a focus on:
(1) Big data-driven identification and prediction of multimorbidity trajectories;
(2) Multi-omics-based investigation into the etiological mechanisms of multimorbidity
1. National Natural Science Foundation of China, "Dynamic Multimorbidity Trajectory and Genetic Association Based on a Mega Cohort", 2024 – 2026, ¥300,000, Ongoing, PI
2. China National Postdoctoral Program for Innovative Talents, "Investigating Causal Relationships and Interactions Among Genes, Lifestyle, and Cardiometabolic Multimorbidity", 2022 – 2025, ¥230,000, Completed, PI
3. China Postdoctoral Science Foundation Grant (First Class, 72nd Batch), "Genetic Susceptibility and Mortality Risk at Different Stages of Cardiometabolic Multimorbidity", 2022 –2025, ¥120,000, Completed, PI
1. Han Y, Hu Y, Yu C, Guo Y, Pei P, Yang L, Chen Y, Du H, Sun D, Pang Y, Chen N, Clarke R, Chen J, Chen Z, Li L*, Lv J*, China Kadoorie Biobank Collaborative G. Lifestyle, cardiometabolic disease, and multimorbidity in a prospective Chinese study. Eur Heart J 2021;42:3374–3384.
2. Han Y, Hu Y, Yu C, Sun D, Pang Y, Pei P, Yang L, Chen Y, Du H, Liu J, Schmidt D, Avery D, Chen J, Chen Z, Li L*, Lv J*. Duration-dependent impact of cardiometabolic diseases and multimorbidity on all-cause and cause-specific mortality: a prospective cohort study of 0.5 million participants. Cardiovasc Diabetol 2023;22(1):135.
3. Han Y, Shi H, Yu C, Pei P, Yang L, Millwood IY, Walters RG, Chen Y, Du H, Guan M, Avery D, Chen J, Chen Z, Li L*, Sun D*, Lv J*. Genetic Risk and Prognosis of the First Incident Stroke Survivors: Findings from China Kadoorie Biobank and UK Biobank. Neurology 2025.
4. Han Y#, Zhu X#, Hu Y, Yu C, Guo Y, Hang D, Pang Y, Pei P, Ma H, Sun D, Yang L, Chen Y, Du H, Yu M, Chen J, Chen Z, Huo D, Jin G, Lv J*, Hu Z, Shen H, Li L. Electronic Health Record–Based Absolute Risk Prediction Model for Esophageal Cancer in the Chinese Population: Model Development and External Validation. JMIR Public Health Surveill 2023;9:e43725.
5. Han Y, Lv J, Yu C, Guo Y, Bian Z, Hu Y, Yang L, Chen Y, Du H, Zhao F, Wen W, Shu XO, Xiang Y, Gao YT, Zheng W, Guo H, Liang P, Chen J, Chen Z, Huo D*, Li L*, China Kadoorie Biobank Collaborative G. Development and external validation of a breast cancer absolute risk prediction model in Chinese population. Breast cancer research : BCR 2021;23:62.
6. Zhu M#, Han Y#, Mou Y#, Meng X#, Ji C, Zhu X, Yu C, Sun D, Yang L, Sun Q, Chen Y, Du H, Dai J, Chen Z, Hu Z, Lv J, Jin G, Ma H, Kan H*, Li L*, Shen H*. Effect of Long-Term Fine Particulate Matter Exposure on Lung Cancer Incidence and Mortality in Chinese Nonsmokers. Am J Respir Crit Care Med 2025;211(4):600-609.
7. Xu H-M#, Han Y#, Liu Z-C, Yin Z-Y, Wang M-Y, Yu C, Ma J-L, Sun D, Liu W-D, Zhang Y, Zhou T, Zhang J-Y, Pei P, Yang L, Millwood IY, Walters RG, Chen Y, Du H, Chen Z, You W-C, Li L, Pan K-F*, Lv J*, Li W-Q*. Helicobacter pylori Treatment and Gastric Cancer Risk Among Individuals With High Genetic Risk for Gastric Cancer. JAMA Netw Open 2024;7(5):e2413708.
8. Zhu M#, Zhu X#, Han Y#, Ma Z, Ji C, Wang T, Yan C, Song C, Yu C, Sun D, Jiang Y, Chen J, Yang L, Chen Y, Du H, Walters R, Millwood IY, Dai J, Ma H, Zhang Z, Chen Z, Hu Z, Lv J, Jin G, Li L, Shen H, Group on behalf of the CKBC. Polygenic risk scores for pan-cancer risk prediction in the Chinese population: A population-based cohort study based on the China Kadoorie Biobank. PLOS Medicine 2025;22(2):e1004534.
9. Han Y, He Y, Lyu J, Yu C, Bian M, Lee L*. Aging in China: perspectives on public health. Global Health Journal 2020;4:11–17.
10. Han Y, Lv J, Yu C, Li L. Development and applications of digital public health. Chinese Journal of Epidemiology, 2022, 43(6): 791-797.