Aiguo Ren

Environmental pollutants and birth defects

Nutritional factors and birth defects

Genetics and birth defects

Epigenetics and birth defects

1. Environmental Determinants of Major Birth Defects       07/2016 – 06/2021

Grant No.: 2016YFC1000501

Funding source: Ministry of Science and Technology, China

Role: Principal Investigator

Role: Co-Principal Investigator

2. Neural Tube Defects: Neural Tube Defects induced by Polycyclic Aromatic Hydrocarbons and Oxidative Stress as an Underlying Mechanism of Teratogenicity         01/2014 – 12/2017

Grant No.: 31371523

Funding source: National Natural Science Foundation of China

Role: Principal Investigator

3. Apoptosis Induced by Polycyclic Aromatic Hydrocarbons and the Underlying Mechanism in the Development of Neural Tube Defects in Mice            01/2014 – 12/2016

Grant No.: 20130001110064

Funding source: Ministry of Education

Role: Principal Investigator

4. Study of Neural Tube Defects Etiology: Genome and Exposome       08/2012 – 06/2015

Grant No. 1R01ES021006-01A1

Funding source: National Institute of Health, USA

Role: Co- Principal Investigator

5. Maternal Exposure to Polycyclic Aromatic Hydrocarbons and the Risk of Neural Tube Defects in the Offspring        01/2011 – 12/2013

Grant No.: 31071315

Funding source: National Natural Science Foundation of China

Role: Principal Investigator

6. Investigation into the Causes for Birth Defects Cluster in Northern China   05/2002-12/2003

Grant No.: 2002BA709B11

Funding source: Ministry of Science and Technology, People’s Republic of China

Role: Principal Investigator

1. Huang Y, Ren A, Wang L, Jin L, Lin S, Li Z, et al. Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure. Clin Epigenetics. 2019;11(1):72.

2. Pi X, Wei Y, Li Z, Jin L, Liu J, Zhang Y, et al. Higher concentration of selenium in placental tissues is associated with reduced risk for orofacial clefts. Clin Nutr. 2019.

3. Lin S, Ren A, Wang L, Santos C, Huang Y, Jin L, et al. Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons. Clin Epigenetics. 2019;11(1):13.

4. Pi X, Jin L, Li Z, Liu J, Zhang Y, Wang L, et al. Association between concentrations of barium and aluminum in placental tissues and risk for orofacial clefts. Sci Total Environ. 2019;652:406-12.

5. Lin S, Ren A, Wang L, Huang Y, Wang Y, Wang C, et al. Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects. Free Radical Biology and Medicine. 2018;116:149-58.

6. Wang L, Lin S, Zhang J, Tian T, Jin L, Ren A. Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis. Epigenetics. 2017;12(2):157-65.

7. Jin L, Liu J, Ye B, Ren A. Concentrations of selected heavy metals in maternal blood and associated factors in rural areas in Shanxi Province, China. Environment International. 2014;66(0):157-64.

8. Wang L, Li Z, Jin L, Li K, Yuan Y, Fu Y, et al. Indoor air pollution and neural tube defects: effect modification by maternal genes. Epidemiology. 2014;25(5):658-65.

9. Ren A, Qiu X, Jin L, Ma J, Li Z, Zhang L, et al. Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(31):12770-5.

10. Li Z, Zhang L, Ye R, Pei L, Liu J, Zheng X, et al. Indoor air pollution from coal combustion and the risk of neural tube defects in a rural population in Shanxi Province, China. American Journal of Epidemiology. 2011;174(4):451-8.