Biyun Yao

Associate Professor
Yaoby@bjmu.edu.cn
Xueyuan Road 38, Haidian District, Beijing, China
Peking University

Personal profile

Education：

Sep. 2003 – Jul. 2006 Ph.D., Department of Toxicology, School of Public Health, Peking University, Beijing, China

Sep.1994 – Jul.1997 M.D., Department of Environmental Health, School of Public Health, Peking University, Beijing, China

Sep.1985 – Jul. 1990 B.S., Department of Public Health, Baotou Medical College, Baotou, Inner Mongolia, China

Work Experience:

Aug.2006 - Present Associate Professor, Department of Toxicology, School of Public Health, Peking University

Jul. 1990 - Sep.2003 Lecturer，Department of Environmental Health，Baotou Medical College

Dr. Yao mainly engaged in teaching and research works of Toxicology. She published more than 30 papers in domestic and foreign magazines and participated in writing a number of toxicology textbooks and monographs. Dr. Yao is a member of Standing Committee of the Toxicology Branch of the Chinese Preventive Medicine Association, the Biochemical and Molecular Toxicology Committee of the Chinese Society of Toxicology. She is also an expert of National Medical Examination Center. She won the third prize of Beijing Science and Technology Progress Award in 2001 and was awarded the excellent teacher of Peking University Health Science Center in 2011 and 2017.

Main research directions

Cellular and Molecular Toxicology; Neuro-toxicology; QSAR Toxicity Prediction.

Representative scientific research projects

1. CHOP, Sig-1R and ERS are Involved in Manganese-Induced Neurotoxicity (2009-2011), Funded by National Natural Science Foundation of China (NSFC, Grant No. 30972502), Project Principal.

2. Comprehensive Study on The Mechanisms Underlying Manganese-induced Neurotransmitter Disorder, Neurodegeneration-Related Proteins Accumulation and Cell Death in Neurons (2011-2014), Funded by NSFC (Grant No. 81172693), Project Principal.

3. The Comparative Study of Manganese and MPTP-induced Neurodegeneration- related Protein Expression and Autophagy (2015-2017)，Funded by BJNS (Grant No. 7150284), Project Principal.

4. The Study of Roles and Intervention of TFEB/CTSD Mediated Autophagy-lysosome Pathway in Manganese-induced Neurotoxicity (2019-2021), Funded by BJNS (Grant No. 7192099), Project Principal.

10 representative papers

1. Dou CS, Zhi CN, Liu WL, Fu JL, Yao BY*. The comparison of neurobehavioral changes and impaired locations between the mouse model of manganism and Parkinson's disease. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018;36(2):84-90. （in Chinese）

2. Liu WL, Dou CS, Wang Y, Zhao P, Fu JL, Yao BY*, Zhou ZC. Oxidative stress and autophagy in SK-N-SH cells induced by manganese chloride or 1-methyl-4-phenylpyridinium: a comparative analysis. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2017;35(2):96-100. （in Chinese）

3. Hongtao Zhang, Lan Mi, Ting Wang, Biyun Yao*, ZongCan Zhou*. PINK1/Parkin-mediated mitophagy play a protective role in manganese induced apoptosis in SH-SY5Y cells. Toxicology in Vitro 2016 (34) 212–219.

4. Gao Ya，Chen Hui-ming，Li Hai-shan，Shen Guo-lin，Yao Bi-yun*，Zhou Zong-can Prediction the toxicity of important components in Chinese herbal medicine by TOPKAT and Derek. J Toxicol; 2016; 30 (5): 339-341（in Chinese）

5. Ting Wang, Xuehui Li, Hongtao Zhang, Biyun Yao*, Zongcan Zhou, ER stress and ER stress-mediated apoptosis are involved in Manganese-induced neurotoxicity in the rat striatum in vivo. NeuroToxicology, 2015(48):109–119.

6. Ya Gao, Biyun Yao*, Zongcan Zhou*. The establishment of toxicity database of important ingredients in Chinese herbal medicine predicted by QSAR. J Toxicol; 2015; (29): 399-401（in Chinese）

7. Zhao P, Fu JL, Yao BY, Jia YR, Zhou ZC. S phase cell percentage normalized BrdU incorporation rate, a new parameter for determining S arrest. Biomed Environ Sci. 2014;27(3):215-9.

8. Zhao P, Fu J, Yao B, Song Y, Yuan L, Jia Y, Ma S, Chen W, Zhou Z..The cell cycle distribution should be given more consideration in cell-based in vitro toxicological studies. Arch Toxicol. 2014;88(2):337-43.

9. Yao B, Fu J, Hu E, Qi Y, Zhou Z. The effects of over-expression and suppression of Cdc25A on the S-phase checkpoint induced by benzo(a)pyrene.Toxicology. 2008;246(2-3):180-7.

10. Yao B, Fu J, Hu E, Qi Y, Zhou Z. The Cdc25A is involved in S-phase checkpoint induced by benzo(a)pyrene.Toxicology. 2007;237(1-3):210-217