Hui Zhou

Research Professor
zhouhui@bjmu.edu.cn
Xueyuan Road 38, Haidian District, Beijing, China
Peking University

Personal profile

Prof. Zhou had graduated from the Department of Physics, Nanjing University in 2001 and received his PhD degree on Biochemistry and Molecular Biology in the Institute of Biophysics, Chinese Academy of Sciences in 2007. From 2008 to 2013, he was engaged in postdoctoral research at National Institute of Environmental Health Sciences (NIEHS) of National Institutes of Health (NIH). From 2013, Prof. Zhou worked in the Department of Occupational and Environmental Health Sciences in Peking University Health Science Center. He mainly focused the toxic effects and related mechanism of environmental pollutants in nervous system diseases, especially in neurodegenerative diseases, and then explored the biomarkers or of environmental toxins. Based on the support of grants from the National Natural Science Foundation of China and the Beijing Natural Science Foundation, Prof. Zhou had published over 20 papers in reputable journals such as Journal of Immunology, Free Radical Biology and Medicine, Toxicology and Applied Pharmacology, and he also served as a reviewer of several decent journals such as Journal of Neuroinflammation and a member of professional committee on precise nutrition in Wu Jieping Medical Foundation of China.

Main research directions

1. Studies on the health effects and related mechanism of environmental risk factors in central neuron system;

2. Studies on therapeutic targets and biomarkers in environmental toxins induced neurotoxicology;

3. Studies on toxic evaluation of environmental risk factors;

Representative scientific research projects

1. National Natural Science Foundation of China [Grant No. 21577004],

2. Beijing Municipal Natural Science Foundation [Grant No. 7162104],

3. Outstanding Young Foundation of Peking University [Grant No. BMU20130340].

10 representative papers

1. D Liu, B Cao, YJ Zhao, HH Huang, RS McIntyre, JD Rosenblat, Hui Zhou, Soluble TREM2 changes during the clinical course of Alzheimer’s disease: A meta-analysis, Neuroscience Letters, 2018, 686，10-16

2. HF Zhang, D Liu, HH Huang, YJ Zhao and Hui Zhou, Characteristics of Insulin-degrading Enzyme in Alzheimer's Disease: A Meta-Analysis, Current Alzheimer Research, 2018, 15, 1-8

3. HF Zhang, D Liu，YX Wang，HH Huang，YJ Zhao，Hui Zhou, Meta-analysis of expression and function of neprilysin in Alzheimer's disease. Neuroscience Letter, 2017, 657: 69-76

4. YX Wang, D Liu, HF Zhang, YX Wang, L Wei, YT Liu, JY Liao, HM Gao, Hui Zhou, Ultrafine carbon particles promote rotenone-induced dopamine neuronal loss through activating microglial NADPH oxidase, Toxicology and Applied Pharmacology, 2017, 322:51-59

5. Hui Zhou, JY Liao, H Nie, F Zhang, JS Hong, H-M Gao, CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses, Journal of Immunology, 2013, 190(1):115-25 (F1000 recommended)

6. H-M Gao, Hui Zhou, Jau-Shyong Hong, NADPH oxidases: novel therapeutic targets for neurodegenerative diseases, Trends in Pharmacological Sciences, 2012, 33(6):295-303

7. Hui Zhou, Feng Zhang, Shih-heng Chen et al, Rotenone activates phagocyte NADPH oxidase through binding to its membrane subunit gp91phox, Free Radical Biology and Medicine, 2012, 52(2):303-313

8. QS Wang, Hui Zhou, Hui-Ming Gao et al, Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase. Journal of Neuroinflammation, 2012, 9:32-46

9. Hui Zhou, Xiaoming Hu, Dan Zhang et al, Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation, Journal of Neuroimmune Pharmacology, 2012, 7(1):187-201

10. HM Gao, Hui Zhou, Feng Zhang et al, HMGB1 acts on microglia Mac-1 to mediate chronic neuroinflammation that drives progressive neurodegeneration, Journal of Neuroscience, 2011, 31(3):1081–1092