倪雪冰

课题组致力于新发传染病的溯源预警与传播机制解析，聚焦病毒跨物种传播与进化动力学的关键科学问题。主要研究方向如下：

1. 病毒进化溯源与适应性机制

整合基因组学与系统发育分析，解析病毒跨宿主传播的关键进化规律与分子驱动机制。

2. 病毒溢出的生态学模型

构建“生态-宿主-病毒”交互模型，量化评估气候变化、生境破坏及人类活动对病毒跨物种传播风险的影响。

3. 智能预警与风险预测

融合多源数据与人工智能算法，开发新病原主动发现与传播风险动态预测系统，支撑前瞻性防控决策。

课题组招募研究助理、博士生、博士后，欢迎对传染病流行病学、进化基因组学、生物信息学等方向感兴趣的同学联系和加入。

1. Ni XB, Ye YT, Wang GP, et al. Ecological factors and genetic features are associated with ecological generalism in pathogenic tick-borne viruses. Nature Communications. 2026. (In Press)

2. Ni XB, Pei Y, Ye YT, et al. Eco-climate drivers shape virome diversity in a globally invasive tick species. The ISME Journal. 2024;18:wrae087.

3. Ni XB, Cui XM, Liu JY, et al. Metavirome of 31 tick species provides a compendium of  1,801 RNA virus genomes. Nature Microbiology. 2023;8:162-173.

4. Du LF, Zhang MZ, Yuan TT, Ni XB (Co-first author), et al. New insights into the impact of microbiome on horizontal and vertical transmission of a tick-borne pathogen. Microbiome. 2023;11:50.

5. Jia N, Liu HB, Ni XB (Co-first author), et al. Emergence of human infection with Jingmen tick virus in China: A retrospective study. EBioMedicine. 2019;43:317-324.

6. Li LJ, Ning NZ, Zheng YC, Chu YL, Cui XM, Guo WB, Wei R, Liu HB, Sun Y, Ye JL, Jiang BG, Yuan TT, Li J, Bian C, Bell-Sakyi L, Wang H, Jiang JF, Song JL, Cao WC, Lam TTY, Ni XB (Co-corresponding author), Jia N. Virome and blood meal-associated host responses in Ixodes persulcatus naturally fed on patients. Frontiers in Microbiology. 2022;12:728996.

7. Jia N, Wang JF, Shi WQ, Du LF, Sun Y, Zhan W, Jiang JF, Wang Q, Zhang B, Ji PF, Lesley BS, Cui XM, Yuan TT, Jiang BG, Yang WF, Lam TTY, Chang QC, Ding SJ, Wang XJ, Zhu JG, Zhao L, Wei JT, Ye RZ, Que TC, Du CH, Zhou YH, Li LF, Wei W, Gao YC, Liu JZ, Shao HZ, Wang X, Wang CC, Yang TC, Huo QB, Li W, Chen HY, Chen SE, Zhou LG, Ni XB, et al. Large-scale comparative analyses of tick genomes elucidate their genetic diversity and vector capacities. Cell. 2020;182:1328-1340.

8. Lam TTY, Jia N, Zhang YW, Shum MHH, Jiang JF, Zhu HC, Tong YG, Ni XB, et al. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins. Nature.   2020;583:282-285.

9. Jiang JF, Zheng YC, Jiang RR, Li H, Huo QB, Jiang BG, Sun Y, Jia N, Wang YW, Ma L, Liu HB, Chu YL, Ni XB, et al. Epidemiological, clinical, and laboratory characteristics of 48 cases of Babesia venatorum infection in China: a descriptive study. The Lancet Infectious Diseases. 2015;15:196-203.

10. Ni XB, Jia N, Jiang BG, et al. Diverse genospecies of Borrelia burgdorferi sensu lato causing Lyme Borreliosis in China. Clinical Microbiology and Infection. 2014;20:808-814.