王辉

妇幼代谢相关疾病的危险因素及干预措施研究

1. 国家自然科学基金青年项目：81402741, 2015/01-2017/12，IRAK家族基因与HBV感染相关肝癌遗传易感性及其机制研究，23万，结题，主持。

2. 唐仲英基金(2022-B126), 儿童非酒精性脂肪性肝病的早期干预, 2022-08 至 2025-12, 16万元, 在研, 主持。

3. 北京大学, 青年培育项目, BMU2022PY018, ERLIN1/2-TM6SF2-APOB通路基因变异与膳食因素对儿童NAFLD的分子流行病学研究, 2022-01 至 2022-12, 8万元, 结题, 主持。

4. 国家自然科学基金委员会, 国际(地区)合作与交流项目, 72361147521, 营养目标下的食物供给与消费均衡研究, 2024-01-01 至 2028-12-31, 199.6万元, 在研, 参与。

5. 国家卫生健康委科学研究基金, 浙江省卫生健康重大科技计划项目, WKJ-ZJ-2216, 基于结构方程模型解析儿童青少年肥胖的干预效果以及优化干预策略, 2022-01 至 2024-12, 100万元, 在研, 骨干。

1. Xu M, Xu T, Li J, Zhang P, Wang H*, Wang Y*, Li L. Time reallocation to moderate-to-vigorous physical activity and its association with chronic kidney disease prevalence in Chinese adults with type 2 diabetes. Diabetes Res Clin Pract. 2025.(IF=7.1, Q1)

2. Wang Y, Qiu D, Zhang P, Shen F, Xu M, Wang H*, Li L*. Appetitive traits and their associations with social anxiety and depression in school-aged children: A cross-sectional study. Appetite. 2025 Aug 27:108276.（IF=3.8, Q1）

3. Wang Y, Zhang P, Wang M, Gong Q, Yu C, Wang H, Hebestreit A, Lau PWC, Wang H*, Li L*. Isotemporal Substitution Effects of Daily Time Use on Cardiorespiratory Fitness of Children in the OptiChild Study: A Mediation Analysis with Diet Quality. Nutrients. 2024 (IF=5.0, Q1)

4. Liu Y, Wang Y, Xing Y, Wolters M, Shi D, Zhang P, Dang J, Chen Z, Cai S, Wang Y, Liu J, Wang X, Zhou H, Xu M, Guo L, Li Y, Song J, Li J, Dong Y, Cui Y, Hu P, Hebestreit A, Wang HJ, Li L, Ma J, Yeo YH, Wang H*, Song Y*. Establish a noninvasive model to screen metabolic dysfunction-associated steatotic liver disease in children aged 6-14 years in China and its applications in high-obesity-risk countries and regions. Lancet Reg Health West Pac. 2024 (IF=8.1, Q1)

5. Zhang PP, Wang YX, Shen FJ, Xing YF, Gu JY, Li XY, Jin H, Jin SF, Xu M, Wang HJ, Wang H*, Li L*. Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study). Trials. 2024 (IF=2.0, Q3)

6. Xing Y, Gao X, Li Q, Li X, Wang Y, Yang Y, Yang S, Lau PWC, Zeng Q*, Wang H*. Associations between exposure to ambient particulate matter and advanced liver fibrosis in Chinese MAFLD patients. J Hazard Mater. 2023 (IF=11.3, Q1)

7. Xing Y, Zhang P, Li X, Jin S, Xu M, Jia J, Wang HJ, Li L*, Wang H*. New predictive models and indices for screening MAFLD in school-aged overweight/obese children. Eur J Pediatr. 2023. (IF=2.6, Q1)

8. Wang Hui#, Wang Yang#, Song Jie-Yun, Zhang Ping-ping Zhang, Song Qi-Ying, Li Chen-Xiong, Li Li, Hai-Jun Wang*. Associations of genetic variants of lysophosphatidylcholine metabolic enzymes with levels of serum lipids. Pediatr Res (IF: 3.1, Q1). 2021 May 2.doi: 10.1038/s41390-021-01549-9.

9. Wang H#, El Maadidi S#, Fischer J, Grabski E, Dickhöfer S, Klimosch S, Flannery SM, Filomena A, Wolz OO, Schneiderhan-Marra N, Löffler MW, Wiese M, Pichulik T, Müllhaupt B, Semela D, Dufour JF, Bochud PY, Bowie AG, Kalinke U, Berg T, Weber AN; East-German and Swiss Hepatitis C Virus Study Groups. A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance. Hepatology. 2015. （IF=11.7, Q1）

10.        Wang H#, Flannery SM, Dickhöfer S, Huhn S, George J, Kubarenko AV, Lascorz J, Bevier M, Willemsen J, Pichulik T, Schafmayer C, Binder M, Manoury B, Paludan SR, Alarcon-Riquelme M, Bowie AG, Försti A, Weber ANR. A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival. J Biol Chem. 2014. (IF=4.5, Q1)