高旭

助理教授、副研究员、博士生导师
xu.gao@hsc.pku.edu.cn
北京市海淀区学院路38号
北京大学

个人简介

北京大学公共卫生学院劳动卫生与环境卫生学系助理教授、副研究员、博士生导师。主要从事基于表观遗传组学及人群大数据，结合其他多组学数据（基因组、代谢组、微生物组等）的环境与衰老及老年健康的流行病学研究。目前已在Nature Aging、Nature Communications、American Journal of Respiratory and Critical Care Medicine、Environmental Health Perspectives、Environmental Science & Technology、International Journal of Epidemiology和 European Journal of Epidemiology等国际权威期刊发表SCI论文60余篇，并担任Current Environmental Health Reports编委，以及The Innovation和环境卫生学杂志青年编委。

教育及工作经历

2006 – 2011 学士（预防医学）复旦大学

2011 – 2014 硕士（病原生物学）复旦大学

2014 – 2018 博士（流行病学，最高荣誉summa cum laude）海德堡大学（德国）

2018 – 2020 博士后研究员（环境健康学）哥伦比亚大学（美国）

主要研究方向

环境与衰老；老年健康；表观遗传流行病学

代表性科研项目

1.中国疾病预防控制中心环境与人群健康重点实验室开放基金（2022-CKL-03）：镉与砷慢性暴露对老年人虚弱状态的影响及 DNA 甲基化机制研究。 2022.01-2023.12 主持

2.国家重点研发计划（2022YFC3702704）：中国居民对大气污染响应的全生命过程健康效应谱研究。2022.10-2026.03 项目骨干

3.美国NIH R01 基金（R01ES025225）: Circulating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging Cohort. 2018 – 2020 参与

4.美国NIH R01 基金（R01ES027747）: Air Particulate, Metals, and Cognitive Performance in an Aging Cohort – Roles of Circulating Extracellular Vesicles and Non-coding RNAs. 2018 – 2020 参与

5.意大利嘉利堡基金会Fondazione Cariplo老龄化疾病研究专项（2017-0653）：The Trithorax and Polycomb group proteins UTX and EzH2 in the Frailty Syndrome. 2017-2020 参与

10篇代表性论文

1. Gao X*, Tong G, Jiang M, Huang N, Zheng Y, Belsky D*, Huang T. Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants. Nature Communications, 2023, doi: 10.1038/s41467-023-38013-7. (IF = 17.694)

2. Gao X*, Jiang M, Huang N, Guo X, Huang T. Long-Term Air Pollution, Genetic Susceptibility, and the Risk of Depression and Anxiety: A Prospective Study in the UK Biobank Cohort. Environmental Health Perspectives, 2023, doi: 10.1289/EHP10391. (IF = 11.035)

3. Gao X#, Huang J#, Cardenas A, Zhao Y, Sun Y, Wang J, Xue L, Baccarelli AA, Guo X, Zhang L, Wu S. Short-Term Exposure of PM2.5 and Epigenetic Aging: A Quasi-Experimental Study. Environmental Science & Technology, 2022, doi: 10.1021/acs.est.2c05534. (IF = 11.357)

4. Gao X*, Huang N, Jiang M, Holleczek B, Schöttker B, Huang T, Brenner H. Mortality and morbidity risk prediction for older former smokers based on a score of smoking history: evidence from UK Biobank and ESTHER cohorts. Age and Ageing, 2022, afac154. doi: 10.1093/ageing/afac154. (IF = 12.782)

5. Gao X*, Huang N, Guo X, Huang T. Role of sleep quality in the acceleration of biological aging and its potential for preventive interaction on air pollution insults: Findings from the UK Biobank cohort. Aging cell, 2022, e13610. doi: 10.1111/acel.13610. (IF = 11.005)

6. Gao X*, Coull B, Lin X, Vokonas P, Spiro A III, Hou L, Schwartz J, Baccarelli AA. Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study. Nature Aging. 2021; 1(5):430-437. doi:10.1038/s43587-021-00060-4. （Nature Aging当期封面文章）

7. Gao X*, Coull B, Lin X, Vokonas P, Sparrow D, Hou L, DeMeo D, Litonjua A, Schwartz J, Baccarelli AA. Association of Neutrophil to Lymphocyte Ratio with Reduced Pulmonary Function in a 30-Year Longitudinal Study of US Veterans. JAMA Network Open. 2020; 3:e2010350. (IF = 13.353)

8. Gao X*, Coull B, Lin X, Vokonas P, Schwartz J, Baccarelli AA. Nonsteroidal anti-inflammatory drugs modify the effect of short-term air pollution on lung function. American Journal of Respiratory and Critical Care Medicine. 2020; 201(3):374-8. (IF = 30.528)

9. Gao X*, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Wang C, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA. Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males. International Journal of Epidemiology. 2019; 48, 1958-1971. (IF = 9.685)

10. Gao X, Gào X, Zhang Y, Holleczek B, Schöttker B, Brenner H. Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people. European Journal of Epidemiology. 2019; 451-462. (IF = 12.434)