高旭

助理教授、副研究员、博士生导师
xu.gao@hsc.pku.edu.cn
北京市海淀区学院路38号
北京大学

个人简介

北京大学公共卫生学院劳动卫生与环境卫生学系助理教授、副研究员、博士生导师。主要从事以人群大数据为基础，利用表观遗传组学，并结合其他多组学数据（基因组，代谢组、微生物组等）的环境暴露与老年健康的流行病学研究。目前已在Nature Aging、American Journal of Respiratory and Critical Care Medicine、Journal of Hazardous Materials, Environment International、International Journal of Epidemiology和 European Journal of Epidemiology等国际权威期刊发表SCI论文40余篇，并担任Current Environmental Health Reports和The Innovation期刊编委。

教育及工作经历

2006 – 2011 学士（预防医学）复旦大学

2011 – 2014 硕士（病原生物学）复旦大学

2014 – 2018 博士（流行病学，最高荣誉summa cum laude）海德堡大学（德国）

2018 – 2020 博士后研究员（环境健康学）哥伦比亚大学（美国）

主要研究方向

环境和老年健康的流行病学；表观遗传流行病学

代表性科研项目

1. 中国疾病预防控制中心环境与人群健康重点实验室开放基金（2022-CKL-03）. 2022.01-2023.12 主持

2. 美国NIH R01 基金（R01ES025225）: Circulating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging Cohort. 2018 – 2020 参与

3. 美国NIH R01 基金（R01ES027747）: Air Particulate, Metals, and Cognitive Performance in an Aging Cohort – Roles of Circulating Extracellular Vesicles and Non-coding RNAs. 2018 – 2020 参与

4. 意大利嘉利堡基金会Fondazione Cariplo老龄化疾病研究专项（2017-0653）：The Trithorax and Polycomb group proteins UTX and EzH2 in the Frailty Syndrome. 2017-2020 参与

10篇代表性论文

1. Gao X*, Koutrakis P, Coull B, Lin X, Vokonas P, Schwartz J, Baccarelli AA. Short-term exposure to PM2.5 components and renal health: findings from the Veterans Affairs Normative Aging Study. Journal of Hazardous Materials. 2021; 420:126557. doi: 10.1016/j.jhazmat.2021.126557. （IF = 10.588）

2. Gao X*, Coull B, Lin X, Vokonas P, Spiro A III, Hou L, Schwartz J, Baccarelli AA. Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study. Nature Aging. 2021; 1(5):430-437. doi:10.1038/s43587-021-00060-4. （Nature Aging当期封面文章）

3. Gao X*, Coull B, Lin X, Vokonas P, Sparrow D, Hou L, DeMeo D, Litonjua A, Schwartz J, Baccarelli AA. Association of Neutrophil to Lymphocyte Ratio with Reduced Pulmonary Function in a 30-Year Longitudinal Study of US Veterans. JAMA Network Open. 2020; 3:e2010350. (IF = 8.483)

4. Gao X*, Coull B, Lin X, Vokonas P, Schwartz J, Baccarelli AA. Nonsteroidal anti-inflammatory drugs modify the effect of short-term air pollution on lung function. American Journal of Respiratory and Critical Care Medicine. 2020; 201(3):374-8. (IF = 21.405)

5. Gao X*, Koutrakis P, Blomberg A, Coull B, Vokonas P, Schwartz J, Baccarelli AA. Short-term ambient particle radioactivity level and renal function in older men: Insight from the Normative Aging Study. Environment International. 2019; 131, 105018-25. (IF = 9.621)

6. Gao X*, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Wang C, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA. Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males. International Journal of Epidemiology. 2019; 48, 1958-1971. (IF = 7.196)

7. Gao X*, Colicino E, Shen J, Just AC, Kioumourtzoglou MA, Nwanaji-Enwerem JC, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA. Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective. Environment International. 2019; 126, 395-405. (IF = 9.621)

8. Gao X, Gào X, Zhang Y, Holleczek B, Schöttker B, Brenner H. Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people. European Journal of Epidemiology. 2019; 451-462. (IF = 8.082)

9. Gao X, Zhang Y, Brenner H. Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic aging in older adults. British Journal of Cancer. 2017; 117 (8), 1211. (IF = 7.640)

10. Gao X, Gào X, Zhang Y, Breitling LP, Schöttker B, Brenner H. Associations of self-reported smoking, cotinine levels and epigenetic smoking indicators with oxidative stress among older adults: a population-based study. European Journal of Epidemiology. 2017; 32(5):443-456. (IF = 8.082)