ENGLISH

师资队伍

高旭

高旭

高旭

  • 副研究员、助理教授、博士生导师
  • xu.gao@hsc.pku.edu.cn
  • 北京市海淀区学院路38号
  • 北京大学
个人简介

北京大学公共卫生学院劳动卫生与环境卫生学系副研究员、博士生导师。主要从事精准环境健康与衰老流行病学研究。目前已在Nature Aging、Nature Cardiovascular Research、Nature Communications、American Journal of Respiratory and Critical Care Medicine、Environmental Health Perspectives、Environmental Science & Technology、International Journal of Epidemiology和 European Journal of Epidemiology等国际权威期刊发表SCI论文70余篇,承担国家自然科学基金、国家重点研发计划等。受聘国际环境流行病学会ISEE执行委员、中华预防医学会环境卫生分会委员、中国老年医学学会流行病学与疾病预防分会委员等。担任呼吸医学顶级杂志Thorax统计编辑,Current Environmental Health Reports常务编委,Biomedical and Environmental Sciences杂志编委,以及Circulation、European Heart Journal、Nature Aging、Nature Sustainability等50余本学术期刊审稿人。


教育及工作经历

2006 – 2011 学士(预防医学) 复旦大学

2011 – 2014 硕士(基础医学)  复旦大学

2014 – 2018 博士(流行病学,最高荣誉summa cum laude)  海德堡大学(德国)

2018 – 2020 博士后研究员(环境健康学) 哥伦比亚大学(美国)


主要研究方向

流行病学;衰老;精准环境健康;脑健康;老年健康;


代表性科研项目

1. 国家自然科学基金(82304098):基于SLC25A51基因甲基化动态调控研究黑碳损伤老年人认知功能的作用机制。2024.1 – 2026.12 主持

2. 广西环境暴露组学与全生命周期健康重点实验室开放课题(2023-GKLEH-03):老年人环境重金属暴露与生物学年龄的长寿队列研究。2023.10-2025.09 主持

3. 中国疾病预防控制中心环境与人群健康重点实验室开放基金(2022-CKL-03):镉与砷慢性暴露对老年人虚弱状态的影响及 DNA 甲基化机制研究。 2022.01-2023.12 主持

4. 国家重点研发计划(2023YFC3603400):我国长寿人群的生命健康要素和延缓衰老靶标研究。2023.12-2026.11 子课题负责人

5. 国家重点研发计划(2022YFC3702704):中国居民对大气污染响应的全生命过程健康效应谱研究。2022.10-2026.03 项目骨干

6. 美国NIH R01 基金 (R01ES025225): Circulating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging Cohort. 2018 – 2020 参与

7. 美国NIH R01 基金 (R01ES027747): Air Particulate, Metals, and Cognitive Performance in an Aging Cohort – Roles of Circulating Extracellular Vesicles and Non-coding RNAs. 2018 – 2020 参与

8. 意大利嘉利堡基金会Fondazione Cariplo老龄化疾病研究专项(2017-0653):The Trithorax and Polycomb group proteins UTX and EzH2 in the Frailty Syndrome. 2017-2020 参与


10篇代表性论文

1. Wang Y#, Li H#, Huang J#, Jiang M, Tian S, Liu S, Zhang L*#, Wu S*#, Kan H*#, Gao X*#. Short-term PM2.5 exposure and DNA methylation changes of circadian rhythm genes: Evidence from two experimental studies. Environmental Science & Technology, 2024; 58 (23), 9991–10000. doi: 10.1021/acs.est.4c00108.

2. Jiang M, Tian S, Liu S, Wang Y, Guo X, Huang T, Lin X, Belsky D, Baccarelli AA, Gao X*. Accelerated biological aging elevates the risk of cardiometabolic multimorbidity and mortality. Nature Cardiovascular Research, 2024. doi: 10.1038/s44161-024-00438-8. (专题报道)

3. Gao X*, Tian S, Huang N, Sun G, Huang T. Associations of daily sedentary behavior, physical activity, and sleep with irritable bowel syndrome: a prospective analysis of 362,193 participants. Journal of Sport and Health Science. 2024; 13 (1), 72-80. doi: 10.1016/j.jshs.2023.02.002. (ESI高被引)

4. Gao X*, Tong G, Jiang M, Huang N, Zheng Y, Belsky D*, Huang T. Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants. Nature Communications, 2023, doi: 10.1038/s41467-023-38013-7. (ESI高被引)

5. Gao X*, Jiang M, Huang N, Guo X, Huang T. Long-Term Air Pollution, Genetic Susceptibility, and the Risk of Depression and Anxiety: A Prospective Study in the UK Biobank Cohort. Environmental Health Perspectives, 2023, doi: 10.1289/EHP10391. (ESI高被引)

6. Gao X#, Huang J#, Cardenas A, Zhao Y, Sun Y, Wang J, Xue L, Baccarelli AA, Guo X, Zhang L, Wu S. Short-Term Exposure of PM2.5 and Epigenetic Aging: A Quasi-Experimental Study. Environmental Science & Technology, 2022, doi: 10.1021/acs.est.2c05534.

7. Gao X*, Coull B, Lin X, Vokonas P, Spiro A III, Hou L, Schwartz J, Baccarelli AA. Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study. Nature Aging. 2021; 1(5):430-437. doi:10.1038/s43587-021-00060-4. (封面文章)

8. Gao X*, Coull B, Lin X, Vokonas P, Sparrow D, Hou L, DeMeo D, Litonjua A, Schwartz J, Baccarelli AA. Association of Neutrophil to Lymphocyte Ratio with Reduced Pulmonary Function in a 30-Year Longitudinal Study of US Veterans. JAMA Network Open. 2020; 3:e2010350.

9. Gao X*, Coull B, Lin X, Vokonas P, Schwartz J, Baccarelli AA. Nonsteroidal anti-inflammatory drugs modify the effect of short-term air pollution on lung function. American Journal of Respiratory and Critical Care Medicine. 2020; 201(3):374-8.

10. Gao X, Gào X, Zhang Y, Holleczek B, Schöttker B, Brenner H*. Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people. European Journal of Epidemiology. 2019; 451-462.