肖武生

心血管和呼吸系统疾病是影响人群健康的主要疾病，其发生与危害和环境污染密切相关。本课题组围绕能量代谢和氧化还原稳态两大机制，探究环境危害暴露（1）如何导致心肺血管损伤和（2）如何加剧心肺血管疾病的风险。

课题一：能量代谢与心肺血管损伤和疾病

能量代谢是维持所有生命活动的基础机制。代谢紊乱可导致心肺血管疾病等众多疾病和不良健康结局的发生与发展。我们致力于研究细胞代谢通路和代谢物水平改变对环境因素（如重金属和新污染物等）致心肺血管系统毒性的调控机制和防治。

课题二：氧化还原应激与心肺血管损伤和疾病

氧化还原稳态是由细胞的抗氧化（抗氧化酶和非酶类抗氧化剂）和促氧化体系（氧自由基和氮自由基）共同精细维持。两大体系失衡将引起氧化应激和还原应激，两者均可造成细胞功能损伤。我们致力于研究环境污染物暴露如何打破氧化还原体系的平衡，导致心肺血管系统氧化和还原损伤。

1. 主持北京市自然基金面上项目（7252186；2025-2027）：糖酵解酶PFKFB3调控镉致血管内皮早期损伤的免疫代谢机制

2. 主持中国CDC环境与人群健康重点实验室开放基金项目（2024-CKL-02；2024-2026）：芳烃受体调控镉致血管内皮早期损伤的免疫代谢机制

3. 主持山西医科大学煤炭环境致病与防治教育部重点实验室开放基金项目（MEKLCEPP/SXMU-201413；2024-2026）：矿区环境水平相当的镉暴露致肺纤维化的免疫代谢机制

4. 主持北京大学临床医学+X青年专项（PKU2023LCXQ005；2023）：KLF4调控肺动脉高压的免疫代谢机制研究

1. Xiao W, Shrimali N, Vigder N, Oldham WM, Clish CB, He H, Wong SJ, Wertheim BM, Arons E, Haigis MC, Leopold JA, Loscalzo J. Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells. Nature Metabolism. 2024. 6: 2138-2156.

2. Xiao W, Oldham WM, Priolo C, Pandey AK, Loscalzo J. Immunometabolic endothelial phenotypes: integrating inflammation and glucose metabolism. Circulation Research. 2021, 129: 9-29.

3. Cui K, Li L, Li K, Xiao W*, Wang Q*. AOP-based framework for predicting the joint action mode of di-(2-ethylhexyl) phthalate and bisphenol A co-exposure on autism spectrum disorder. Neurotoxicology. 2024, 104: 75-84.（*共通讯作者）

4. Li K, Zhang Y, Li L, Cui K, Li Y, Li C, Dai Y*, Xiao W*, Wang Q*. Identification of sensitive endpoints for the assessment of phthalates-induced reproductive and developmental toxicity: a literature mining study. Food and Chemical Toxicology. 2024, 188: 114686.（*共通讯作者）

5. Xiao W and Loscalzo J. Metabolic response to reductive stress. Antioxidants & Redox Signaling. 2020, 32: 1330-1347.（ESI高引论文）

6. Xiao W, Wang RS, Handy DE, Loscalzo J. NAD(H) and NADP(H) redox couples and cellular energy metabolism. Antioxidants & Redox Signaling. 2018, 28: 251-272.（ESI高引论文）

7. He H, Mulhern RM, Oldham WM, Xiao W, Lin Y, Liao R, Loscalzo J. L-2-hydroxyglutarate protects against cardiac injury via metabolic remodeling. Circulation Research. 2022, 131: 562-579.

8. Pandey A, Waldeck-Weirmair M, Wells Q, Xiao W, Yadav S, Eroglu E, Michel T, Loscalzo J. Expression of CD70 modulates nitric oxide and redox status in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022, 42: 1169-1185.

9. Xiao W, Sarsour EH, Wagner BA, Doskey CM., Buettner GR, Domann FE, Goswami PC. Succinate dehydrogenase activity regulates PCB3-quinone induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes. Archives of Toxicology. 2016, 90: 319-332.

10. Xiao W, Zhu Y, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone induced oxidative stress and toxicity in human keratinocytes. Free Radical Biology and Medicine. 2013, 65: 70-77.