王琳琳

研究员、博士生导师
linlinwang@bjmu.edu.cn
北京市海淀区学院路38号
北京大学

个人简介

主要从事生育健康及出生缺陷病因机制的研究与应用，阐明了生育健康问题的发生发展规律，为重大出生缺陷的病因和发病机制提供了新的科学证据，为人群预防提供了科学支撑，取得了一系列成果。先后主持国家社科基金重大项目课题、科技部国家重点研发计划课题、国家自然科学基金及北京市自然科学基金项目，参与美国国立卫生研究院资助项目等科研项目。以第一或通讯作者在Environmental Science Technology、Journal of Hazardous Materials、Clinical Epigenetics、Human Genetics、Epidemiology等权威期刊发表论文80余篇，其中SCI论文60余篇；参与编写中英文专著8部；获授权发明专利多项（已转化2项）。开设研究生课程“流行病学与精准医学”和本科生课程“精准营养学”。担任北京大学生育健康研究所副所长，国家卫生健康委生育健康重点实验室副主任，兼任国家科技部项目会评专家，国家基金委面青地项目会评专家，卫健委人才交流服务中心高级人才评价项目专家，中国生殖健康产业协会标准化技术委员会专家，中国医药教育协会健康管理专委会副主委兼秘书长，中国环境诱变剂学会致畸专委会常委，中国妇幼保健协会出生缺陷防治与分子遗传分会常委等。获北京市科学技术奖、教育部科研成果奖、中华医学会科技奖、中华预防医学科学技术奖、美国CDC Charles C. Shepard Science Awards Nominations，深圳市科学技术奖专利奖等多项科研奖励。

主要研究方向

分子流行病学、生育健康流行病学、精准营养学

以上研究方向常年招聘博士后（博士）、科研助理（研究生）、实习生（本科生），欢迎联系咨询。

代表性科研项目

1. Li S, Wang C, Yang C, Chen Y, Cheng Q, Liu J, Zhang Y, Jin L, Li Z, Ren A, Wang L*. Prenatal exposure to poly/perfluoroalkyl substances and risk for congenital heart disease in offspring. Journal of Hazardous Materials, 2024,469:134008.

2. Yang C, Ning X, Wang B, Tian T, Chen Y, Ma L*, Wang L*. Association between spectrum of mycotoxins and semen quality: A cross-sectional study in Beijing, China. Journal of Hazardous Materials. 2024, 476: 135124.

3. Liu L, Guo Q, Cui M, Liu J, Yang C, Li X, Liu P*, Wang L*. Impact of maternal nutrition during early pregnancy and diet during lactation on lactoferrin in mature breast milk. Nutrition, 2022, 93, 111500.

4. Chen Y, Liu L, Ni W, Jin L, Li Z, Ren A, Wang L*. Association between selected alkaline earth elements concentrations in umbilical cord and risk for cleft lip with or without cleft palate. Science of the Total Environment, 2021,750:141735.

5. Tian T, Lei Y, Chen Y, Karki M, Jin L, Finnell RH, Wang L*, Ren A*. Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects. Human Genetics, 2020,139(10):1299-1314.

6. Guo Y, Liu L, Ni W, Pan Y, Chen Y, Xie Q, Liu Y, Jin L, Li Z, Ren A, Wang L*. Uranium concentration in umbilical cord may increase the risk for orofacial clefts. Environmental Research, 2020, 182, 109103.

7. Lin S, Ren A*, Wang L*, Santos C, Huang Y, Jin L, Li Z, Greene NDE. Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons. Clin Epigenetics 2019;11(1):13.

8. Ni W, Yang W, Jin L, Liu J, Li Z, Wang B, Wang L*, Ren A. Levels of polycyclic aromatic hydrocarbons in umbilical cord and risk of orofacial clefts, Science of the Total Environment, 2019, 678: 123-132.

9. Ni W, Yang W, Yu J, Li Z, Jin L, Liu J, Zhang Y, Wang L*, Ren A. Umbilical Cord Concentrations of Selected Heavy Metals and Risk for Orofacial Clefts. Environmental Science & Technology, 2018,52(18):10787-10795.

10. Wang L, Li Z*, Jin L, Li K, Yuan Y, Fu Y, Zhang Y, Ye R, Ren A*. Indoor air pollution and neural tube defects: effect modification by maternal genes. Epidemiology 2014;25(5):658-65.

10篇代表性论文

1. Li, S., Wang, C., Yang, C., Chen, Y., Cheng, Q., Liu, J., Zhang, Y., Jin, L., Li, Z., Ren, A., Wang LL*. Prenatal Exposure to Poly/Perfluoroalkyl Substances and Risk for Congenital Heart Disease in Offspring. Journal of Hazardous Materials, 2024, 469: 134008.

2. Yang, C., Ning, X., Wang, B., Tian, T., Chen, Y., Ma, L.*, & Wang LL*.Association between spectrum of mycotoxins and semen quality: A cross-sectional study in Beijing, China. Journal of Hazardous Materials, 2024, 476: 135124.

3. Zhu, H., Cheng, Q., Liu, J., Jin, L., Li, Z., Ren, A., Wang LL*. Associations among bisphenol A, its analogs, and chlorinated derivatives in placenta and risk for neural tube defects: A case-control study. Sci Total Environ, 2023, 900: 165586.

4. Yang, C., Guo, Q., Cui, M., Li, X., Zhang, J., Peng, X., Liu, J., Liu, P. *, Wang LL*. Association between maternal metabolic profiles in pregnancy, dietary patterns during lactation and breast milk leptin: a retrospective cohort study. Br J Nutr, 2023, 130(9): 1537-1547.

5. Wang C., Pi X., Chen Y., Wang D., Yin S., Jin L., Li Z., Ren A*, Wang LL*. and Yin C*. Prenatal exposure to barium and the occurrence of neural tube defects in offspring. Sci Total Environ. 2021;764:144245.

6. Liu L, Guo Q, Liu P*, Wang LL*. Impact of maternal albumin and hemoglobin during early pregnancy and diet during lactation on lactoferrin in mature human milk. Nutrition. 2022;93:111500.

7. Tian T, Lei YP, Chen YY, Karki M, Jin L, Finnell RH, Wang LL*, Ren AG*. Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects. Hum Genet. 2020;139(10):1299-314.

8. Chen Y, Liu L, Ni W, Jin L, Li Z, Ren A, Wang LL*. Association between selected alkaline earth elements concentrations in umbilical cord and risk for cleft lip with or without cleft palate. Sci Total Environ 2020; 750:141735.

9. Huang Y, Ren A*, Wang LL*, Jin L, Lin S, Li Z, McDonald JA. Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure. Clin Epigenetics 2019;11(1):72.

10. Ni W, Yang W, Yu J, Li Z, Jin L, Liu J, Zhang Y, Wang LL*, Ren A. Umbilical Cord Concentrations of Selected Heavy Metals and Risk for Orofacial Clefts. Environmental Science & Technology 2018; 52:10787-95.