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靳蕾

靳蕾

靳蕾

  • 副研究员、博士生导师
  • jinlei@bjmu.edu.cn
  • 北京市海淀区学院路38号
  • 北京大学
个人简介

北京大学流行病学专业博士。

主持、参与多项国家和省部级科研课题。发表科研论文175篇,其中第一作者或责任作者论文59篇。

《中国生育健康杂志》编委,中国妇幼保健协会出生缺陷防治与分子遗传分会委员,中国环境科学学会环境医学与健康分会委员。


主要研究方向

生育健康流行病学;出生缺陷病因研究;环境与生殖健康

代表性科研项目

1. 国家社会科学基金, 重大项目, 人口老龄化背景下的发育性残疾预防策略与应用研究2021–2024,项目骨干。

2. 国家科技部, 重点研发计划项目“环境和表观遗传变化在结构性出生缺陷发生中的作用和致病机制,2021–2024,项目骨干。

3. 国家科技部重点研发计划项目 “母胎糖脂代谢互作的生物标志物筛选与分子机制解析”,2021–2024,项目骨干。

4. 国家科技部重点研发计划项目“基于内外环境暴露监测的环境和行为因素对胚胎发育与妊娠影响研究”课题“基于外暴露监测的环境和行为因素对胚胎发育与妊娠影响的队列研究”,2018–2021,项目骨干。

5. 国家科技部重点研发计划“常见重大出生缺陷病因学及早期预防策略研究”课题“环境因素导致重要器官发育异常的关键环节”,2016–2021,项目骨干。


10篇代表性论文

1. Li Y, Li Z, Wang C, Yang M, He Z, Wang F, Zhang Y, Li R, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Shi P, Wang N, Wei Z, Wang YL, Jin L*, Du P*, Dong J*, Jiao J*. Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain [J]. Cell, 2023, Doi: 10.1016/j.cell.2023.11.016.

2. Yin SJ, Sun Y, Yu JH, Su ZM, Tong MK, Zhang YL, Liu JF, Wang LL, Li ZW, Ren AG*, Jin L*. A High Concentration of Polycyclic Aromatic Hydrocarbons in Umbilical Cord Tissue is Associated with an Increased Risk for Fetal Neural Tube Defects [J]. Exposure and Health, 2022, Doi: 10.1007/s12403-022-00476-2.

3. Wang D, Jin L, Zhang J, Meng W, Ren A, Jin L*. Maternal Periconceptional Folic Acid Supplementation and Risk for Fetal Congenital Heart Defects [J]. J Pediatr, 2022, 240(72-8. Doi: 10.1016/j.jpeds.2021.09.004.

4. Li Y, Li Z, Yang M, Wang F, Zhang Y, Li R, Li Q, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Ong J, Teng Z, Jin L*, Wang YL*, Du P*, Jiao J*. Decoding the temporal and regional specification of microglia in the developing human brain [J]. Cell Stem Cell, 2022, 29(7): 620-34. Doi: 10.1016/j.stem.2022.02.004.

5. Yin S; Sun Y; Yu J; Su Z; Tong M; Zhang Y; Liu J; Wang L; Li Z; Ren A*; Jin L*; Prenatal exposure to organochlorine pesticides is associated with increased risk for neural tube defects [J]. The Science of the Total Environment, 2021,770:145284. Doi: 10.1016/j.scitotenv.2021.145284

6. Tong M; Yu J; Liu M; Li Z; Wang L; Yin C; Ren A; Chen L*; Jin L*; Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring  [J]. Environment International, 2021, 150:106425. Doi: 10.1016/j.envint.2021.106425.

7. Jin L, Jin L, Yu J, Xu Y, Liu H, Ren A. Prevalence of Neural Tube Defects and the Impact of Prenatal Diagnosis in Three Districts of Beijing, China. Paediatric and perinatal epidemiology. 2017,31:293-300. Doi: 10.1111/ppe.12354.

8. Jin L, Liu, M, Zhang L, Li Z, Yu J, Liu J, Ye R, Chen L*, Ren A*. Exposure of methyl mercury in utero and the risk of neural tube defects in a Chinese population. Reproductive toxicology. 2016, 61:131-5. Doi: 10.1016/j.reprotox.2016.03.040.

9. Wang B, Jin L, Ren A*, Yuan Y, Liu J, Li Z, Zhang L, Yi D, Wang L, Zhang Y, Wang X, Tao S, Finnell RH. Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring. Environ Sci Technol, 2015, 49(1): 588-96. Doi: 10.1021/es503990v. (并列第一作者)

10. Jin L, Liu J, Ye B, Ren A*. Concentrations of selected heavy metals in maternal blood and associated factors in rural areas in Shanxi Province, China. Environ Int, 2014, 66:157-164. Doi: 10.1016/j.envint.2014.01.016.