Zhiwen Li

Professor
lizw@bjmu.edu.cn
Xueyuan Road 38, Haidian District, Beijing, China
Peking University

Personal profile

MD, PhD of Epidemiology and statistics; Deputy director with Institute of Reproductive and Child Health, School of Public Health, Peking University; Deputy director with Key Laboratory of Reproductive Health, National Health Commission of China; Chairman of professional committee on environment and reproductive health, Chinese Association of Eugenic Science; Vice Chairman of professional committee on environment and reproductive health, Chinese Environmental Mutagen Society; Editorial Board Member for International Journal of Environmental Research and Public Health (ISSN 1660-4601); Editorial Board Member for Chinese Journal of Reproductive Health. As principal investigator or key investigator, he has undertaken many projects sponsored by National Key Research and Development Program of China, National Natural Science Foundation of China, Beijing Natural Science Foundation, etc. As the first or corresponding author, he has published more than 90 academic papers. He has also been granted one Chinese invention and two utility model patent rights.

Main research directions

Reproductive and perinatal epidemiology

Environmental etiology and mechanisms of adverse pregnancy outcomes such as birth defects and preterm birth

Representative scientific research projects

1. Beijing Natural Science Foundation: Association of serum copper level in early pregnancy with lipid metabolism and risk of spontaneous preterm birth(7222248), 2022/01-2024/12, Principal Investigator.

2. National Natural Science Foundation of China: Synergistic effect and toxicity mechanisms of combined exposure of polycyclic aromatic hydrocarbons on the fetal neural tube defects(81973056), 2020/01-2023/12, Principal Investigator.

3. National Key Research and Development Program of China: Effect of novel coronavirus pneumonia epidemic on adverse pregnancy outcomes in pregnant women(2020YFC0846300)，2020/04-2021/06, Principal Investigator.

4. National Natural Science Foundation of China: The inductive effect and mechanisms of polycyclic aromatic hydrocarbons on spontaneous preterm births and the prevention of folic acid (No: 81673177), 2017/01-2020/12, Principal Investigator.

5. National Natural Science Foundation of China(China-UK cooperation): Environmental and genetic determinants of neural tube defects (No: 81511130088), 2015/04-2017/12, Principal Investigator.

6. National Natural Science Foundation of China: The effect of maternal passive smoking during early pregnancy on risk of neural tube defects in offspring and the potential mechanisms (No: 81373014), 2014/01-2017/12, Principal Investigator.

7. National Key Research and Development Program of China: The role of environmental and epigenetic changes in occurrence of structural birth defects and their pathogenic mechanisms (2021YFC2701001), 2021/12-2024/11, Key Investigator.

8. National Key Research and Development Program of China: Key links of environment induced abnormal development of important organs (No.2016YFC1000501), 2016/07-2021/06, Key Investigator.

10 representative papers

1. Xu R, Meng X, Pang Y, An H, Wang B, Zhang L, Ye R, Ren A, Li Z*, Gong J*. Associations of maternal exposure to 41 metals/metalloids during early pregnancy with the risk of spontaneous preterm birth: Does oxidative stress or DNA methylation play a crucial role? Environ Int. 2022 Jan;158:106966. SCI IF2021= 9.621/Q1；

2. Jia X, Zhang L, Zhao J, Ren M, Li Z, Wang J, Wang S, Liu Y, An H, Li Y, Yan L, Li Z*, Liu X*, Pan B*, Ye R. Associations between endocrine-disrupting heavy metals in maternal hair and gestational diabetes mellitus: A nested case-control study in China. Environ Int. 2021 Dec;157:106770. SCI IF2021= 9.621/Q1；

3. Ren M, Jia X, Shi J, Yan L, Li Z, Lan C, Chen J, Li N, Li K, Huang J, Wu S, Lu Q, Li Z*, Wang B*, Liu J. Simultaneous analysis of typical halogenated endocrine disrupting chemicals and metal(loid)s in human hair. Sci Total Environ. 2020 May 20;718:137300. SCI IF2019= 6.5519/Q1；

4. Liu J, Li Z*, Ye R, Ren A, Liu J. Folic acid supplementation and risk for congenital limb reduction defects in China. Int J Epidemiol. 2019 Dec 1;48(6):2010-2017.SCI IF2019 = 7.339/Q1；

5. Yu Y, Gao M, Wang X, Guo Y, Pang Y, Yan H, Hao Y, Zhang Y, Zhang L, Ye R, Wang B*, Li Z*. Recommended acceptable levels of maternal serum typical toxic metals from the perspective of spontaneous preterm birth in Shanxi Province, China. Sci Total Environ. 2019 Oct 10;686:599-605. SCI IF2019= 6.5519/Q1；

6. Wang B#*, Zhu Y#, Yan L, Zhang J, Wang X, Cheng H, Li Z*, Ye R, Ren A. Association of maternal chronic arsenic exposure with the risk of neural tube defects in Northern China. Environ Int. 2019 May;126:222-227. SCI IF2019= 7.943/Q1；

7. Li Z, Wang B*, Huo W, Liu Y, Zhu Y, Xie J, Li Z*, Ren A. Are concentrations of alkaline earth elements in maternal hair associated with risk of neural tube defects? Sci Total Environ. 2017 Dec 31;609:694-700. SCI IF2017 =4.900/Q1；

8. Huo W, Zhu Y, Li Z, Pang Y, Wang B, Li Z*. A pilot study on the association between rare earth elements in maternal hair and the risk of neural tube defects in north China. Environ Pollut. 2017 Jul; 226:89-93. SCI IF2017 = 5.099/Q1；

9. Li Z, Mei Z, Zhang L, Li H, Zhang Y, Li N, Ye R, Ren A, Liu JM, Serdula MK. Effects of Prenatal Micronutrients Supplementation on Spontaneous Preterm Birth: Double-Blind Randomized Controlled Trial in China. Am J Epidemiol. 2017 Aug 1;186(3):318-325. SCI IF2017 = 4.825/Q1；

10. Li Z, Ye R, Zhang L, Li H, Liu J, Ren A. Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study. Int J Epidemiol. 2014 Aug;43(4):1132-9. SCI IF2014 = 9.197/Q1；