Xuetao Wei

Associate Professor
weixt@263.net
Xueyuan Road 38, Haidian District, Beijing, China
Peking University

Personal profile

1992 graduated from Beijing medical university, 2008 graduated from department of nutrition and food hygiene for Ph.D.

From 1992 to 2000, in Beijing medical university worked as teaching assistant and lecturer. From 2003 till now worked as associate professor in department of toxicology, Peking University. Among this period in 2010, worked as visiting scholar in department of comparative molecular biology and pathology, John Hopkins University and from 2012-2013, worked as visiting scientist in department of immunology and microbiology, Keio University in Japan.

Currently serve as director of teaching office and deputy director of department of toxicology. Also take the position of deputy secretory general and executive manager in Chinese Environmental Mutagenesis Society, Permanent council in committee of toxicological education (Chinese society of toxicology), Permanent council in committee of immunotoxicology (Chinese society of toxicology), Committee member of GM safety committee of the Ministry of Agriculture, Committee member of national agriculture GM biosafety administrative standardization technical committees, Director of toxicological division in functional food evaluation and research center of Peking university.

Main research directions

Immunotoxicology

Molecular and cellular toxicology

Environmental pollution

Pharmaceutical toxicology

Immune modulation of bioactive agents

Safety evaluation and risk assessment

Representative scientific research projects

1. Research and Development of Novel Assessment Technologies on Key Issues in Food Toxicology for Biological Breeding Products Granted by Major Special Project of Agricultural Biological Breeding

2. Development of New Technologies and Models for Food and Environmental Safety Assessment of Gene-Edited Products Granted by National key research and development program

3. Ferritin - IL-33 related toxicity pathway in respiratory inflammation induced by aged carbon black Granted by National natural science foundation of China

4. Safety evaluation of rare-earth elements and additive in foods based on the toxic mechanism and health effect endpoint. Granted by National key research and development program.

5. Environmental exposure and health effect of secondary particulate and ozone. Supported by Major program of National natural science foundation of China.

6. The environmental chemical behavior, ecology and toxic effect of rare-earth in agriculture. Supported by Major program of National natural science foundation of China.

7. Research of contraception methods for male--Toxicological issues of LTQ in the process of anti-fertility. Granted by National key technology support program.

8. Effect of copper excess on immune system. Granted by international copper association.

9. The role of TAK1 and TAB1 in allergy. Granted by Roche pharmaceutical Ltd.

10 representative papers

1. Yuan Cui, Qianqian Xiao, Qiong Zhang, Jiawei Yang, Yuetong Liu, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei*. 1,2-bis(2,4,6-tribromophenoxy) ethane induces necroptosis via the co-competition of GAS5 and NUAK1 for miR-743a-5p in rat hepatocytes. J Hazard Mater. 2024 Oct 5:478:135375.

2. Yuese Yuan, Yimeng Zhuang, Yuan Cui, Yuetong Liu, Qiong Zhang, Qianqian Xiao, Qinghe Meng, Jianjun Jiang, Weidong Hao, Xuetao Wei*. Effects of 1, 2-bis (2,4, 6-tribromophenoxy) ethane and bis (2-ethylhexyl) tetrabromophthalate on serum metabolic and lipid profiles in male rats. Toxicol Appl Pharmacol. 2024 Sep: 490: 117020.

3. Yuan Cui, Qianqian Xiao, Zhenyu Wang, Qiong Zhang, Yuetong Liu, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei*. 1,2-bis(2,4,6-tribromophenoxy) ethane, a novel brominated flame retardant, disrupts intestinal barrier function via the IRX3/NOS2 axis in rat small intestine. J Hazard Mater. 2024 Jan 5:461:132597.

4. Yuese Yuan, Yimeng Zhuang, Yuan Cui, Yuetong Liu, Qiong Zhang, Qianqian Xiao, Qinghe Meng, Jianjun Jiang, Weidong Hao, Xuetao Wei*. IL-10-TG/TPO-T4 axis, the target of bis (2-ethylhexyl) tetrabromophthalate on thyroid function imbalance. Toxicology. 2024 Jan:501:153713.

5. Qiong Zhang, Zhenyu Wang, Qianqian Xiao, Jianhong Ge, Xiaoyun Wang, Wanyu Jiang, Yuese Yuan, Yimeng Zhuang, Qinghe Meng, Jianjun Jiang, Weidong Hao, Xuetao Wei*. The effects and mechanisms of the new brominated flame retardant BTBPE on thyroid toxicity. Food Chem Toxicol. 2023 Oct:180:114027.

6. Yuan Cui, Qianqian Xiao, Qiong Zhang, Yuetong Liu, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei*. Black carbon nanoparticles activate the crosstalk mechanism betweennecroptosis and macrophage extracellular traps to change macrophages fate. Environ Res. 2023 Sep 1;232:116321.

7. Yuan Cui, Qianqian Xiao, Yuese Yuan, Yimeng Zhuang, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei*. Ozone-oxidized black carbon particles change macrophage fate: Crosstalk between necroptosis and macrophage extracellular traps. Environ Pollut. 2023; 329:121655.

8. Yuan Cui, Qianqian Xiao, Yuese Yuan, Yimeng Zhuang, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei*. 1,4-Naphthoquinone-Coated Black Carbon, a Kind of Atmospheric Fine Particulate Matter, Affects Macrophage Fate: New Insights into Crosstalk between Necroptosis and Macrophage Extracellular Traps. Environ Sci Technol. 2023 Apr 18;57(15):6095-6107.

9. Zekang Li, Wanyu Jiang, Hongqian Chu, Jianhong Ge, Xiaoyun Wang, Jianjun Jiang, Qianqian Xiao, Qinghe Meng, Weidong Hao, Xuetao Wei* Exploration of potential mechanism of interleukin-33 up-regulation caused by 1,4-naphthoquinone black carbon in RAW264.7 cells. Sci Total Environ. 2022, 835:155357.

10. Jianhong Ge, Hongqian Chu, Qianqian Xiao, Weidong Hao, Jing Shang, Tong Zhu, Zhaogang Sun, Xuetao Wei*. BC and 1,4NQ-BC up-regulate the cytokines and enhance IL-33 expression in LPS pretreatment of human bronchial epithelial cells. Environ Pollut. 2021, 273:116452