王琳琳

个人简介

王琳琳北京大学医学博士、北京大学公共卫生学院副研究员、硕士生导师(流行病与卫生统计学)、北京大学生育健康研究所副所长。

作为课题负责人或项目主要骨干先后承担或参加国家科技部973项目子课题、国家自然基金面上项目、国家自然基金青年项目、教育部博士点项目、美国CDC资助课题及美国NIH资助课题等共计十余项。发表科研论文30余篇,其中SCI论文16篇。参与编写专著3部。

主要研究方向
分子流行病学,营养流行病学,生育健康
代表性科研项目

国家自然科学基金,孕期母体胎盘及血叶酸受体抗体与胎儿神经管缺陷发生风险的相关性研究(81202215),2013-2015。

教育部博士点基金,孕期母体及胎儿血浆叶酸受体自身抗体与体内叶酸水平的关联性研究(20100001120132),2011-2013。

国家自然科学基金,多环芳烃致胎儿神经管缺陷作用及氧化应激机制研究(31371523),2014-2016。

美国NIH资助课题,出生缺陷病因学研究:基因组与暴露组学(1R01ES021006-01A1),2012-2015,实验室方面骨干。

美国CDC资助课题,孕期增补叶酸、铁和多种维生素,预防孕期、产时、产后和婴儿期不良结局的随机对照研究,2006-2012,实验室方面骨干。

10篇代表性论文

[1]Wang LL, Jin L, Liu J, Zhang Y, Yuan Y, Yi D, Ren A*. Maternal genetic polymorphisms of phase II metabolic enzymes and the risk of fetal neural tube defects. Birth defects research. Part A, Clinical and molecular teratology. 100:13-21, 2014

[2]Wang LL, Li Z*, Jin L, Li K, Yuan Y, Fu Y, Zhang Y, Ye R, Ren A*. Maternal genetic variants of phase I metabolic enzymes modify risk of neural tube defects associated with indoor air pollution exposure. Epidemiology. 2014 Jan (Accepted)

[3]Wang LL, Liu YH, Meng LL, Li CG, Zhou SF*. Phenotype prediction of non-synonymous single-nucleotide polymorphisms in human ATP-binding cassette transporter genes. Basic & clinical pharmacology & toxicology. 108:94-114, 2011

[4]Wang LL, Yang AK, Li Y, Liu JP, Zhou SF*. Phenotype prediction of deleterious nonsynonymous single nucleotide polymorphisms in human alcohol metabolism-related genes: A bioinformatics study. Alcohol.44:425-438, 2010

[5]Wang LL, Yang AK, He SM, Liang J, Zhou ZW, Li Y, Zhou SF*. Identification of molecular targets associated with ethanol toxicity and implications in drug development. Current Pharmaceutical Design. 16(11): 1313-1355, 2010

[6]Wang LL, Li Y, Zhou SF. A bioinformatics approach for the phenotype prediction of nonsynonymous single nucleotide polymorphisms in human cytochromes p450. Drug metabolism and disposition: the biological fate of chemicals. 37:977-991, 2009

[7]Wang LL, Li Y, Zhou SF. Prediction of deleterious non-synonymous single nucleotide polymorphisms of genes related to ethanol-induced toxicity. Toxicology letters. 187:99-114, 2009

[8]Wang LL, Zhang Z, Li Q, Yang R, Pei X, Xu Y, Wang J, Zhou SF, Li Y. Ethanol exposure induces differential microrna and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum Reprod. 24:562-579, 2009

[9]Liu J, Wang LL, Fu Y, Li Z, Zhang Y, Zhang L, Jin L, Ye R, Ren A*. Association between maternal comt gene polymorphisms and fetal neural tube defects risk in a Chinese population. Birth defects research. Part A, Clinical and molecular teratology. 100:22-29, 2014

[10]Yuan Y, Jin L, Wang LL, Li Z, Zhang L, Zhu H, Finnell RH, Zhou G, Ren A*. Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population. Reprod Toxicol. 37:70-75, 2013