周辉

个人简介  

2001年于南京大学物理系获得生物物理学士学位,
2007年于中国科学院生物物理研究所获得生物化学与分子生物学博士学位。
2008年至2013年期间于美国国立健康研究院 (NIH) 环境健康研究所(NIEHS)从事博士后研究,
从事神经毒理与病理的相关工作,主要集中于帕金森病的致病因素及其机制研究等相关领域,主要研究工作进一步揭示了神经免疫在帕金森病中的重要推动作用,并发现在神经免疫中连接外界环境毒物与神经死亡的关键靶点,为神经免疫抑制在帕金森病治疗中的应用奠定理论基础。
目前主要结合环境健康学的相关内容,对当前主要的环境污染物在神经系统疾病、心血管疾病中的致病性及其机制进行探讨,进而促进对此类疾病的预防与治疗。

主要研究方向

环境毒理学、神经毒理学、神经药理学

代表性科研项目

1,大气细颗粒物在神经退行性疾病中致病性及其机制研究

2,农药、杀虫剂导致帕金森病的机制研究

3,神经免疫在环境神经毒性中的作用研究

4,病毒感染引发帕金森病的机理研究

5,环境药理学研究-神经退行性疾病的预防与治疗

代表性的文章

1. Hui Zhou, Jieying Liao, Hui Nie et al, CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses, Journal of Immunology, 2013, 190(1):115-25 (Impact Factor: 5.788) (Recommended by Faculty 1000)

2. Hui-Ming Gao, Hui Zhou, Jau-Shyong Hong, NADPH oxidases: novel therapeutic targets for neurodegenerative diseases, Trends in Pharmacological Sciences, 2012, 2012, 33(6):295-303 (Impact Factor: 10.927)

3. Hui Zhou, Feng Zhang, Shih-heng Chen et al, Rotenone activates phagocyte NADPH oxidase through binding to its membrane subunit gp91phox, Free Radical Biology and Medicine, 2012, 52(2):303-313 (Impact Factor: 5.423)

4. Qingshan Wang, Hui Zhou, Hui-Ming Gao et al, Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase. Journal of Neuroinflammation, 2012, 9:32-46 (Impact Factor: 3.83)

5. Feng Zhang, Hui Zhou, Belinda Wilson et al, Fluoxetine protects neurons against microglial activation-mediated neurotoxicity, Parkinsonism & Related Disorders, 2012, S1:S213-217 (Impact Factor: 3.795)

6. Hui Zhou*, Xiaoming Hu*, Dan Zhang et al, Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation, Journal of Neuroimmune Pharmacology, 2012, 7(1):187-201 (Impact Factor: 4.574)

7. Hui-Ming Gao, Hui Zhou, Feng Zhang et al, HMGB1 acts on microglia Mac-1 to mediate chronic neuroinflammation that drives progressive neurodegeneration, Journal of Neuroscience, 2011, 31(3):1081–1092 (Impact Factor: 7.115) (Recommended by Faculty 1000)

8. Hui-Ming Gao, Feng Zhang, Hui Zhou et al, Alpha-synuclein dysfunction and neuroinflammation potentiates each other driving chronic progression of Parkinson’s disease, Environmental Health Perspective, 2011, 119(6):807-814 (Impact Factor: 7.036)

9. Hui Zhou, Jing Zhao and Xujia Zhang, The inhibition of mitochondrial uncoupling protein 2 by genipin cause insulin resistance in 3T3-L1 adipocytes. Archive of Biochemistry and Biophysics, 2009, 486: 88-93 (Impact Factor: 2.935)

10. Hui Zhou and Xujia Zhang, Advances in the study of mitochondrial uncoupling protein 2. Chinese Bulletin of Life Science, 2008, 20(4): 549-559